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Meta-analysis links cefepime to higher mortality than other beta-lactams

UCLA experts call finding a 'signal, not a verdict'

1 Sep 10 · 14d ago · 1 article · 1 source · development 1 of 4

Daniel Uslan and Ethan Smith of UCLA's David Geffen School of Medicine published an accompanying editorial cautioning that the trials generating the signal bear limited resemblance to contemporary practice. They cited recent trials including ACORN, which showed no significant mortality difference between cefepime and piperacillin-tazobactam, and other studies where cefepime showed lower mortality than comparators.

UCLA experts call finding a 'signal, not a verdict'
NY Post

“This is a signal, not a verdict… the trials that generate this signal bear limited resemblance to contemporary practice.”

Daniel Uslan, MD, and Ethan Smith, PharmD

Zahra Sohani, MD, PhD Lead researcher, Hôpital Maisonneuve-RosemontDaniel Uslan, MD UCLA infectious disease expertEthan Smith, PharmD UCLA pharmacistDr. Marc SiegelDr. Marc Siegel Fox News senior medical analyst

The whole story articles the bright band is this development · numbered dots are the others · click one to jump

Peak 2 pieces in 4h at Sep 10, 10 AM; 9 pieces over 14 days (9 articles) Sep 10, 10 AM — 2 pieces · 2 articles — Newswires 1, Google News 1Sep 10, 2 PM — quietSep 10, 6 PM — quietSep 10, 10 PM — quietSep 11, 2 AM — quietSep 11, 6 AM — quietSep 11, 10 AM — quietSep 11, 2 PM — quietSep 11, 6 PM — quietSep 11, 10 PM — quietSep 12, 2 AM — quietSep 12, 6 AM — quietSep 12, 10 AM — quietSep 12, 2 PM — quietSep 12, 6 PM — quietSep 12, 10 PM — quietSep 13, 2 AM — quietSep 13, 6 AM — quietSep 13, 10 AM — quietSep 13, 2 PM — quietSep 13, 6 PM — quietSep 13, 10 PM — quietSep 14, 2 AM — quietSep 14, 6 AM — 2 pieces · 2 articles — Google News 2Sep 14, 10 AM — quietSep 14, 2 PM — quietSep 14, 6 PM — quietSep 14, 10 PM — quietSep 15, 2 AM — quietSep 15, 6 AM — quietSep 15, 10 AM — quietSep 15, 2 PM — quietSep 15, 6 PM — 2 pieces · 2 articles — Google News 1, Newswires 1Sep 15, 10 PM — quietSep 16, 2 AM — quietSep 16, 6 AM — 1 piece · 1 article — Google News 1Sep 16, 10 AM — 2 pieces · 2 articles — Newswires 1, Google News 1Sep 16, 2 PM — quietSep 16, 6 PM — quietSep 16, 10 PM — quietSep 17, 2 AM — quietSep 17, 6 AM — quietSep 17, 10 AM — quietSep 17, 2 PM — quietSep 17, 6 PM — quietSep 17, 10 PM — quietSep 18, 2 AM — quietSep 18, 6 AM — quietSep 18, 10 AM — quietSep 18, 2 PM — quietSep 18, 6 PM — quietSep 18, 10 PM — quietSep 19, 2 AM — quietSep 19, 6 AM — quietSep 19, 10 AM — quietSep 19, 2 PM — quietSep 19, 6 PM — quietSep 19, 10 PM — quietSep 20, 2 AM — quietSep 20, 6 AM — quietSep 20, 10 AM — quietSep 20, 2 PM — quietSep 20, 6 PM — quietSep 20, 10 PM — quietSep 21, 2 AM — quietSep 21, 6 AM — quietSep 21, 10 AM — quietSep 21, 2 PM — quietSep 21, 6 PM — quietSep 21, 10 PM — quietSep 22, 2 AM — quietSep 22, 6 AM — quietSep 22, 10 AM — quietSep 22, 2 PM — quietSep 22, 6 PM — quietSep 22, 10 PM — quietYesterday, 2 AM — quietYesterday, 6 AM — quietYesterday, 10 AM — quietYesterday, 2 PM — quietYesterday, 6 PM — quietYesterday, 10 PM — quietToday, 2 AM — quietToday, 6 AM — quiet ◂ 1 earlier234
2Study spreads to mainstream medical and…3Fox News and NY Post report finding to…4Fox News medical analyst emphasizes…
Sep 11Sep 12Sep 13Sep 14Sep 15Sep 16Sep 17Sep 18Sep 19Sep 20Sep 21Sep 22now · 8:52 AM ET

Reported in the same hours no headline names this development itself — these 1 claim were published in its stretch

  1. 1 outlet Cefepime and Mortality—A Dosing Problem, Not a Drug Problem

    first by jamanetwork.com, 13d ago

All 4 developments of Meta-analysis links cefepime to higher mortality than other… →

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