Chromatin alterations identified as disease mechanism alongside plaques and tangles
1 Sep 13 9:56 AM · 10d ago · 2 articles · 2 posts · 3 sources · development 1 of 1
The study establishes higher-order chromatin alterations—changes in how DNA and associated proteins package the genome—as a component of Alzheimer's molecular pathology. This expands understanding beyond the classic hallmarks of amyloid-beta plaques and tau tangles, which currently affect seven million Americans.
“Our results establish higher-order chromatin alterations as a component of the molecular pathology associated with the disease, which currently affects seven million Americans, a number that continues to grow.”
Hansruedi Mathys, assistant professor of neurobiology at PittJian Ma Study lead, computational biology professorHansruedi Mathys Co-investigator, neurobiology assistant professorCarnegie Mellon University School of Computer Science Research institutionUniversity of Pittsburgh School of Medicine Research institutionUniversity of Washington Research institution
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first by Science Daily, 10d ago · also Newsweek
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- Scientists Uncover a Hidden Alzheimer’s Clue Deep Inside Brain Cells Newsweek · 7d ago
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DATE: September 13, 2026 at 09:56AM SOURCE: SCIENCE DAILY MIND-BRAIN FEED TITLE: Scientists find a new layer of Alzheimer’s hidden in the genome URL: https://www. sciencedaily.com/releases/2026 /09/260912220051.htm Scientists found that the 3D organization of DNA is disrupted in several types of brain cells affected by Alzheimer’s disease…
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DATE: September 13, 2026 at 09:56AM SOURCE: SCIENCE DAILY PSYCHOLOGY FEED TITLE: Scientists find a new layer of Alzheimer’s hidden in the genome URL: https://www. sciencedaily.com/releases/2026 /09/260912220051.htm Scientists found that the 3D organization of DNA is disrupted in several types of brain cells affected by Alzheimer’s disease…
All 1 developments of Study reveals 3D genome disruption as hidden layer of… →
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