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Rare EGFR mutation tied to 25-fold lung cancer risk in nonsmokers

Researchers publish findings on T790M mutation and lung cancer risk

2 Sep 17 2:00 PM · 6d ago · 1 article · 1 source · development 2 of 2

A team led by Dr. Jaclyn LoPiccolo reports in Science that a rare genetic variant T790M in the EGFR gene is associated with a 25-fold higher odds of lung cancer overall, and 60-fold higher risk among never-smokers. The research used 23andMe genetic data to determine the mutation's prevalence and impact across populations.

Researchers publish findings on T790M mutation and lung cancer risk
statnews.com

“While we knew that T790M was associated with lung cancer, we didn't have a population large enough to determine how common the variant was, how strong its effect, and how the risk varies in different groups.”

Dr. Jaclyn LoPiccolo

Dr. Jaclyn LoPiccolo Lung cancer researcher, Dana Farber Cancer InstituteNadia Litterman Executive director, Susan Wojcicki Foundation23andMe Genetics company

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1–2Researchers publish findings on T790M…
Sep 18Sep 19Sep 20Sep 21Sep 22yesterdaynow · 3:51 AM ET

What was reported 2 claims about this development

  1. 16 outlets Rare EGFR Mutation Tied to Higher Lung Cancer Risk

    first by Mirage News, 6d ago · also The Seattle Times, Yahoo, Science | AAAS, NYT, NYT Health, NYT Science +9

    13 more headlines
  2. 7 outlets STAT+: Why do ‘never smokers’ get lung cancer? In some cases, rare genetic variant may be a factor

    first by STAT News, 6d ago · also TradingView, Boston Globe, STAT, Reuters, ET HealthWorld, The Indian Practitioner

    5 more headlines

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