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Major review finds no causal link between Tylenol in pregnancy and autism or ADHD

Umbrella review of seven meta-analyses finds no causal link between Tylenol and neurodevelopmental disorders

2 Yesterday · 16h ago · 4 articles · 4 posts · 2 sources · development 2 of 2

A comprehensive umbrella review published in Developmental Medicine & Child Neurology, led by Hoda Tayebi Hillali of the University of Santiago de Compostela, analyzed data from seven meta-analyses covering more than 3 million participants. While unrestricted analysis showed slight associations (risk ratios 1.17 for autism, 1.29 for ADHD), high-quality data analysis found no relationship. Authors concluded that apparent associations are "probably influenced by methodological limitations" and that "paracetamol remains an appropriate first-line treatment during pregnancy when clinically indicated."

Umbrella review of seven meta-analyses finds no causal link between Tylenol and neurodevelopmental disorders
metajournal.com

“Our findings show that the apparent association between prenatal paracetamol exposure and autism or ADHD weakens as methodological quality improves, challenging the interpretation of a causal link.”

Hoda Tayebi Hillali, DDS, MSc

Hoda Tayebi Hillali Lead author, umbrella reviewUniversity of Santiago de Compostela Research institutionAmerican Academy of Obstetrics and Gynecology Clinical authority

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1Medscape examines methodological debate…2Umbrella review of seven meta-analyses…
Sep 18Sep 19Sep 20Sep 21Sep 22yesterdaynow · 5:06 AM ET

What was reported 1 claim about this development

  1. 4 outlets Review Finds No Link Between Tylenol Use in Pregnancy and Autism

    first by India News Network, 16h ago · also WSOC TV, CIDRAP, Forbes

    3 more headlines

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All 2 developments of Major review finds no causal link between Tylenol in… →

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