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Researchers develop light-activated protein-degradation cages

Mechanism addresses side-effect problem in protein-degradation therapies

1 Oct 30 · 9d ago · 5 articles · 1 post · 3 sources · development 1 of 1

The RuPHOTAC technology solves a critical limitation of conventional PROTACs: their inability to target specific tissues. Most disease-associated proteins also perform important functions in healthy cells, so systemic protein degradation causes unwanted side effects. RuPHOTACs enable selective activation only in illuminated tissue.

Mechanism addresses side-effect problem in protein-degradation therapies
sflorg.com

“The problem is there are very few targets—like aberrant proteins—that are only found in cancer. Most of the time, the proteins are important for our healthy tissues too. So we need a 'cage'; that is, a way to control when and where these PROTACs are activated.”

Edith C. (Phoebe) Glazer

Edith C. (Phoebe) Glazer Professor of chemistry, North Carolina State University

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Peak 3 pieces in 3h at Oct 29, 2 PM; 6 pieces over 10 days (5 articles · 1 post) Oct 29, 2 PM — 3 pieces · 2 articles · 1 post — Google News 2, Mastodon 1Oct 29, 5 PM — quietOct 29, 8 PM — quietOct 29, 11 PM — quietOct 30, 2 AM — quietOct 30, 5 AM — quietOct 30, 8 AM — quietOct 30, 11 AM — 2 pieces · 2 articles — Google News 1, Newswires 1Oct 30, 2 PM — 1 piece · 1 article — Google News 1Oct 30, 5 PM — quietOct 30, 8 PM — quietOct 30, 11 PM — quietOct 31, 2 AM — quietOct 31, 5 AM — quietOct 31, 8 AM — quietOct 31, 11 AM — quietOct 31, 2 PM — quietOct 31, 5 PM — quietOct 31, 8 PM — quietOct 31, 11 PM — quietNov 1, 1 AM — quietNov 1, 4 AM — quietNov 1, 7 AM — quietNov 1, 10 AM — quietNov 1, 1 PM — quietNov 1, 4 PM — quietNov 1, 7 PM — quietNov 1, 10 PM — quietNov 2, 1 AM — quietNov 2, 4 AM — quietNov 2, 7 AM — quietNov 2, 10 AM — quietNov 2, 1 PM — quietNov 2, 4 PM — quietNov 2, 7 PM — quietNov 2, 10 PM — quietNov 3, 1 AM — quietNov 3, 4 AM — quietNov 3, 7 AM — quietNov 3, 10 AM — quietNov 3, 1 PM — quietNov 3, 4 PM — quietNov 3, 7 PM — quietNov 3, 10 PM — quietNov 4, 1 AM — quietNov 4, 4 AM — quietNov 4, 7 AM — quietNov 4, 10 AM — quietNov 4, 1 PM — quietNov 4, 4 PM — quietNov 4, 7 PM — quietNov 4, 10 PM — quietNov 5, 1 AM — quietNov 5, 4 AM — quietNov 5, 7 AM — quietNov 5, 10 AM — quietNov 5, 1 PM — quietNov 5, 4 PM — quietNov 5, 7 PM — quietNov 5, 10 PM — quietNov 6, 1 AM — quietNov 6, 4 AM — quietNov 6, 7 AM — quietNov 6, 10 AM — quietNov 6, 1 PM — quietNov 6, 4 PM — quietNov 6, 7 PM — quietNov 6, 10 PM — quietYesterday, 1 AM — quietYesterday, 4 AM — quietYesterday, 7 AM — quietYesterday, 10 AM — quietYesterday, 1 PM — quietYesterday, 4 PM — quietYesterday, 7 PM — quietYesterday, 10 PM — quietToday, 1 AM — quietToday, 4 AM — quietToday, 7 AM — quietToday, 10 AM — quiet 1
1Mechanism addresses side-effect problem…
Oct 30Oct 31Nov 1Nov 2Nov 3Nov 4Nov 5Nov 6yesterdaynow · 11:19 AM ET

Reported in the same hours no headline names this development itself — these 1 claim were published in its stretch

  1. 3 outlets Researchers Create Light-Activated Cages for Protein Killers

    first by Mirage News, 9d ago · also The National Tribune, Google News · Health

    2 more headlines

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