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Smart nanoparticles deliver mRNA to tumors, reprogramming immune cells

Wired reports on smart nanoparticle delivery mechanism and preclinical results

1 Sep 16 4:30 AM · 8d ago · 7 articles · 2 posts · 4 sources · development 1 of 1

Coverage details how the researchers added targeting antibodies that bind to TREM2 on immunosuppressive macrophages, ensuring mRNA reaches only tumor-associated cells. The nanoparticles also carried resiquimod to stimulate immune pathways. In mouse models with aggressive breast cancer, three doses reduced immunosuppressive macrophages by 63 percent and increased CXCL9 concentration approximately four times higher than control groups.

Wired reports on smart nanoparticle delivery mechanism and preclinical results
wired.com

“One of the biggest challenges in cancer immunotherapy is that the immune system may be capable of attacking a tumor, but the tumor environment can stop those immune cells from doing their job.”

Chunxia Zhao

Chunxia Zhao University of Adelaide professor, lead researcher

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Peak 7 pieces in 3h at Sep 16, 1 AM; 13 pieces over 13 days (11 articles · 2 posts) Sep 11, 1 PM — 4 pieces · 4 articles — Google News 4Sep 11, 4 PM — quietSep 11, 7 PM — 2 pieces · 2 articles — Google News 2Sep 11, 10 PM — quietSep 12, 1 AM — quietSep 12, 4 AM — quietSep 12, 7 AM — quietSep 12, 10 AM — quietSep 12, 1 PM — quietSep 12, 4 PM — quietSep 12, 7 PM — quietSep 12, 10 PM — quietSep 13, 1 AM — quietSep 13, 4 AM — quietSep 13, 7 AM — quietSep 13, 10 AM — quietSep 13, 1 PM — quietSep 13, 4 PM — quietSep 13, 7 PM — quietSep 13, 10 PM — quietSep 14, 1 AM — quietSep 14, 4 AM — quietSep 14, 7 AM — quietSep 14, 10 AM — quietSep 14, 1 PM — quietSep 14, 4 PM — quietSep 14, 7 PM — quietSep 14, 10 PM — quietSep 15, 1 AM — quietSep 15, 4 AM — quietSep 15, 7 AM — quietSep 15, 10 AM — quietSep 15, 1 PM — quietSep 15, 4 PM — quietSep 15, 7 PM — quietSep 15, 10 PM — quietSep 16, 1 AM — 7 pieces · 5 articles · 2 posts — Google News 3, Mastodon 2, Bluesky 1, +1 moreSep 16, 4 AM — quietSep 16, 7 AM — quietSep 16, 10 AM — quietSep 16, 1 PM — quietSep 16, 4 PM — quietSep 16, 7 PM — quietSep 16, 10 PM — quietSep 17, 1 AM — quietSep 17, 4 AM — quietSep 17, 7 AM — quietSep 17, 10 AM — quietSep 17, 1 PM — quietSep 17, 4 PM — quietSep 17, 7 PM — quietSep 17, 10 PM — quietSep 18, 1 AM — quietSep 18, 4 AM — quietSep 18, 7 AM — quietSep 18, 10 AM — quietSep 18, 1 PM — quietSep 18, 4 PM — quietSep 18, 7 PM — quietSep 18, 10 PM — quietSep 19, 1 AM — quietSep 19, 4 AM — quietSep 19, 7 AM — quietSep 19, 10 AM — quietSep 19, 1 PM — quietSep 19, 4 PM — quietSep 19, 7 PM — quietSep 19, 10 PM — quietSep 20, 1 AM — quietSep 20, 4 AM — quietSep 20, 7 AM — quietSep 20, 10 AM — quietSep 20, 1 PM — quietSep 20, 4 PM — quietSep 20, 7 PM — quietSep 20, 10 PM — quietSep 21, 1 AM — quietSep 21, 4 AM — quietSep 21, 7 AM — quietSep 21, 10 AM — quietSep 21, 1 PM — quietSep 21, 4 PM — quietSep 21, 7 PM — quietSep 21, 10 PM — quietSep 22, 1 AM — quietSep 22, 4 AM — quietSep 22, 7 AM — quietSep 22, 10 AM — quietSep 22, 1 PM — quietSep 22, 4 PM — quietSep 22, 7 PM — quietSep 22, 10 PM — quietYesterday, 1 AM — quietYesterday, 4 AM — quietYesterday, 7 AM — quietYesterday, 10 AM — quietYesterday, 1 PM — quietYesterday, 4 PM — quietYesterday, 7 PM — quietYesterday, 10 PM — quietToday, 1 AM — quietToday, 4 AM — quiet 1
1Wired reports on smart nanoparticle…
Sep 12Sep 13Sep 14Sep 15Sep 16Sep 17Sep 18Sep 19Sep 20Sep 21Sep 22now · 5:48 AM ET

What was reported 3 claims about this development

  1. 4 outlets Smart Nanoparticles Boost Immune Attack on Tumors

    first by Mirage News, 12d ago · also Medical Xpress, Newswise, Nanowerk

    5 more headlines
  2. 1 outlet mRNA Nanoparticles Reprogramme Tumour Immune Environment

    first by EMJ, 8d ago

  3. 1 outlet ‘Smart’ Nanoparticles Deliver mRNA Directly to Tumors in New Cancer Therapy

    first by WIRED, 8d ago

What people said 1 voice · verbatim

All 1 developments of Smart nanoparticles deliver mRNA to tumors, reprogramming… →

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