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HealthQuiet 8d · day 13

Smart nanoparticles deliver mRNA to tumors, reprogramming immune cells

University of Adelaide researchers developed targeted nanoparticles that reprogram immunosuppressive cells in tumors, slowing growth in breast cancer mouse models.

newest coverage 8d agosummary written 8d ago13 pieces210 likes & upvotes3 comments Google NewsNewswiresMastodonBluesky

What to know

  • Smart nanoparticles use antibody targeting to deliver mRNA directly to tumor-associated macrophages, avoiding systemic immune activation risks.
  • The therapy reprograms immunosuppressive cells to produce CXCL9, recruiting T cells to attack tumors.
  • Preclinical results in aggressive breast cancer models showed slowed tumor growth, 63% reduction in immunosuppressive macrophages, and increased T-cell activity after three doses.

“The treatment can reprogram immune cells that have been corrupted by the cancer, strengthening the body's ability to attack.”

Wired, Publication · Wired ↗

Chunxia Zhao University of Adelaide professor, lead researcher

Smart nanoparticles deliver mRNA to tumors, reprogramming immune cells
wired.com

How it unfolded 1 development · click the chart to see its coverage articlesposts

Peak 7 pieces in 3h at Sep 16, 1 AM; 13 pieces over 13 days (11 articles · 2 posts) Sep 11, 1 PM — 4 pieces · 4 articles — Google News 4Sep 11, 4 PM — quietSep 11, 7 PM — 2 pieces · 2 articles — Google News 2Sep 11, 10 PM — quietSep 12, 1 AM — quietSep 12, 4 AM — quietSep 12, 7 AM — quietSep 12, 10 AM — quietSep 12, 1 PM — quietSep 12, 4 PM — quietSep 12, 7 PM — quietSep 12, 10 PM — quietSep 13, 1 AM — quietSep 13, 4 AM — quietSep 13, 7 AM — quietSep 13, 10 AM — quietSep 13, 1 PM — quietSep 13, 4 PM — quietSep 13, 7 PM — quietSep 13, 10 PM — quietSep 14, 1 AM — quietSep 14, 4 AM — quietSep 14, 7 AM — quietSep 14, 10 AM — quietSep 14, 1 PM — quietSep 14, 4 PM — quietSep 14, 7 PM — quietSep 14, 10 PM — quietSep 15, 1 AM — quietSep 15, 4 AM — quietSep 15, 7 AM — quietSep 15, 10 AM — quietSep 15, 1 PM — quietSep 15, 4 PM — quietSep 15, 7 PM — quietSep 15, 10 PM — quietSep 16, 1 AM — 7 pieces · 5 articles · 2 posts — Google News 3, Mastodon 2, Bluesky 1, +1 moreSep 16, 4 AM — quietSep 16, 7 AM — quietSep 16, 10 AM — quietSep 16, 1 PM — quietSep 16, 4 PM — quietSep 16, 7 PM — quietSep 16, 10 PM — quietSep 17, 1 AM — quietSep 17, 4 AM — quietSep 17, 7 AM — quietSep 17, 10 AM — quietSep 17, 1 PM — quietSep 17, 4 PM — quietSep 17, 7 PM — quietSep 17, 10 PM — quietSep 18, 1 AM — quietSep 18, 4 AM — quietSep 18, 7 AM — quietSep 18, 10 AM — quietSep 18, 1 PM — quietSep 18, 4 PM — quietSep 18, 7 PM — quietSep 18, 10 PM — quietSep 19, 1 AM — quietSep 19, 4 AM — quietSep 19, 7 AM — quietSep 19, 10 AM — quietSep 19, 1 PM — quietSep 19, 4 PM — quietSep 19, 7 PM — quietSep 19, 10 PM — quietSep 20, 1 AM — quietSep 20, 4 AM — quietSep 20, 7 AM — quietSep 20, 10 AM — quietSep 20, 1 PM — quietSep 20, 4 PM — quietSep 20, 7 PM — quietSep 20, 10 PM — quietSep 21, 1 AM — quietSep 21, 4 AM — quietSep 21, 7 AM — quietSep 21, 10 AM — quietSep 21, 1 PM — quietSep 21, 4 PM — quietSep 21, 7 PM — quietSep 21, 10 PM — quietSep 22, 1 AM — quietSep 22, 4 AM — quietSep 22, 7 AM — quietSep 22, 10 AM — quietSep 22, 1 PM — quietSep 22, 4 PM — quietSep 22, 7 PM — quietSep 22, 10 PM — quietYesterday, 1 AM — quietYesterday, 4 AM — quietYesterday, 7 AM — quietYesterday, 10 AM — quietYesterday, 1 PM — quietYesterday, 4 PM — quietYesterday, 7 PM — quietYesterday, 10 PM — quietToday, 1 AM — quietToday, 4 AM — quiet 1
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  1. 1

    Wired reports on smart nanoparticle delivery mechanism and preclinical results

    Coverage details how the researchers added targeting antibodies that bind to TREM2 on immunosuppressive macrophages, ensuring mRNA reaches only tumor-associated cells. The nanoparticles also carried resiquimod to stimulate immune pathways. In mouse models with aggressive breast cancer, three doses reduced immunosuppressive macrophages by 63 percent and increased CXCL9 concentration approximately four times higher than control groups.

    “One of the biggest challenges in cancer immunotherapy is that the immune system may be capable of attacking a tumor, but the tumor environment can stop those immune cells from doing their job.”
    — Chunxia Zhao
    1. 4 outlets Smart Nanoparticles Boost Immune Attack on Tumors

      first by Mirage News, 12d ago · also Medical Xpress, Newswise, Nanowerk

      5 more headlines
    2. 1 outlet mRNA Nanoparticles Reprogramme Tumour Immune Environment

      first by EMJ, 8d ago

    1 more claim →
    • wired.com

      The treatment can reprogram immune cells that have been corrupted by the cancer, strengthening the body’s ability to attack.

      wired.comBluesky8d ago204▲view on Bluesky ↗
  2. background

    University of Adelaide team publishes smart nanoparticle cancer therapy study — Researchers led by professor Chunxia Zhao published findings in Science Advances describing a system to deliver mRNA therapy that transforms tumor-associated macrophages back into allies by instructing them to produce CXCL9, a chemical signal for recruiting T cells.