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Lactate takes direct route into heart mitochondria via MCT1 transporter

Cluntun et al. publish MCT1-mediated lactate import pathway in Nature

1 Oct 28 · 14d ago · 2 articles · 1 source · development 1 of 2

A research team reports that lactate can enter mitochondria directly through MCT1, a transporter traditionally thought to reside only on cell membranes. The discovery shows MCT1 also sits in the inner mitochondrial membrane and, working with LDHB, enables lactate conversion to pyruvate and NADH to fuel the electron transport chain.

Cluntun et al. publish MCT1-mediated lactate import pathway in Nature
Nature News

“In the heart, lactate can enter mitochondria directly through a specific transporter protein and this process is essential for cardiac function under stress.”

Trace Thome and Zolt Arany

Ahmad A. Cluntun Lead researcherTrace Thome Cardiovascular researcher, University of PennsylvaniaZolt Arany Cardiovascular researcher, University of Pennsylvania

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1Cluntun et al. publish MCT1-mediated…2Finding distributed through news…
Oct 29Oct 31Nov 2Nov 4Nov 6Nov 8now · 11:34 PM ET

What was reported 1 claim about this development

  1. 2 outlets How the Heart Stays Strong with MCT1-Dependent Mitochondrial Lactate Import

    first by Genetic Engineering and Biotechnology News, 14d ago · also Nature

    1 more headline

All 2 developments of Lactate takes direct route into heart mitochondria via MCT1… →

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