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ScienceQuiet 14d · day 15

Lactate takes direct route into heart mitochondria via MCT1 transporter

Researchers find lactate enters mitochondria directly in heart muscle, challenging decades of assumption about how the heart metabolizes fuel.

newest coverage 13d agosummary written 12d ago5 pieces NewswiresGoogle NewsMastodon

What to know

  • Researchers found MCT1, previously thought to function only at the cell membrane, also exists in the inner mitochondrial membrane of heart cells, enabling direct lactate entry into mitochondria.
  • This parallel lactate pathway bypasses the traditional route through cytosolic pyruvate conversion, allowing simultaneous oxidation of glucose and lactate under stress.
  • Loss of MCT1 function impairs heart metabolism under stress and accelerates heart failure development, making the transporter essential for cardiac function.

“Loss of MCT1 impairs lactate oxidation, disrupts metabolic flexibility and accelerates the development of heart failure with increased mortality after hyperactivation of the neurohormonal axis or ischemia–reperfusion injury.”

Cluntun et al., Research authors · Nature ↗ · Oct 27

Ahmad A. Cluntun Lead researcherTrace Thome Cardiovascular researcher, University of PennsylvaniaZolt Arany Cardiovascular researcher, University of Pennsylvania

Lactate takes direct route into heart mitochondria via MCT1 transporter
Nature News

How it unfolded 2 developments, newest first · click a bar or a number to jump articlesposts

Peak 2 pieces in 4h at Oct 27, 7 PM; 5 pieces over 15 days (4 articles · 1 post) Oct 27, 7 PM — 2 pieces · 2 articles — Newswires 2Oct 27, 11 PM — quietOct 28, 3 AM — quietOct 28, 7 AM — quietOct 28, 11 AM — quietOct 28, 3 PM — 2 pieces · 2 articles — Google News 2Oct 28, 7 PM — quietOct 28, 11 PM — 1 piece · 1 post — Mastodon 1Oct 29, 3 AM — quietOct 29, 7 AM — quietOct 29, 11 AM — quietOct 29, 3 PM — quietOct 29, 7 PM — quietOct 29, 11 PM — quietOct 30, 3 AM — quietOct 30, 7 AM — quietOct 30, 11 AM — quietOct 30, 3 PM — quietOct 30, 7 PM — quietOct 30, 11 PM — quietOct 31, 3 AM — quietOct 31, 7 AM — quietOct 31, 11 AM — quietOct 31, 3 PM — quietOct 31, 7 PM — quietOct 31, 11 PM — quietNov 1, 2 AM — quietNov 1, 6 AM — quietNov 1, 10 AM — quietNov 1, 2 PM — quietNov 1, 6 PM — quietNov 1, 10 PM — quietNov 2, 2 AM — quietNov 2, 6 AM — quietNov 2, 10 AM — quietNov 2, 2 PM — quietNov 2, 6 PM — quietNov 2, 10 PM — quietNov 3, 2 AM — quietNov 3, 6 AM — quietNov 3, 10 AM — quietNov 3, 2 PM — quietNov 3, 6 PM — quietNov 3, 10 PM — quietNov 4, 2 AM — quietNov 4, 6 AM — quietNov 4, 10 AM — quietNov 4, 2 PM — quietNov 4, 6 PM — quietNov 4, 10 PM — quietNov 5, 2 AM — quietNov 5, 6 AM — quietNov 5, 10 AM — quietNov 5, 2 PM — quietNov 5, 6 PM — quietNov 5, 10 PM — quietNov 6, 2 AM — quietNov 6, 6 AM — quietNov 6, 10 AM — quietNov 6, 2 PM — quietNov 6, 6 PM — quietNov 6, 10 PM — quietNov 7, 2 AM — quietNov 7, 6 AM — quietNov 7, 10 AM — quietNov 7, 2 PM — quietNov 7, 6 PM — quietNov 7, 10 PM — quietNov 8, 2 AM — quietNov 8, 6 AM — quietNov 8, 10 AM — quietNov 8, 2 PM — quietNov 8, 6 PM — quietNov 8, 10 PM — quietNov 9, 2 AM — quietNov 9, 6 AM — quietNov 9, 10 AM — quietNov 9, 2 PM — quietNov 9, 6 PM — quietNov 9, 10 PM — quietYesterday, 2 AM — quietYesterday, 6 AM — quietYesterday, 10 AM — quietYesterday, 2 PM — quietYesterday, 6 PM — quietYesterday, 10 PM — quietToday, 2 AM — quietToday, 6 AM — quietToday, 10 AM — quietToday, 2 PM — quietToday, 6 PM — quiet 12
Oct 29Oct 31Nov 2Nov 4Nov 6Nov 8now · 9:51 PM ET
  1. 2

    Finding distributed through news aggregation channels

    The MCT1 research appears in Google News and coverage from Genetic Engineering and Biotechnology News, expanding awareness of the discovery.

    • us@pubeurope.com

      https://www. europesays.com/us/1150770/ MCT1-dependent mitochondrial lactate import sustains cardiac metabolism # Health # HeartFailure # Homeostasis # HumanitiesAndSocialSciences # Metabolomics # multidisciplinary # Science # UnitedStates # UnitedStates # US

      us@pubeurope.comMastodon13d agoview on Mastodon ↗
  2. background

    Discovery defies prevailing dogma about lactate transport — Nature News commentary by Thome and Arany notes the findings overturn the long-standing model in which lactate oxidation requires conversion to pyruvate in the cytosol before mitochondrial entry. The new pathway explains how the heart simultaneously oxidizes both lactate and glucose to meet energetic demand.

  3. 1

    Cluntun et al. publish MCT1-mediated lactate import pathway in Nature

    A research team reports that lactate can enter mitochondria directly through MCT1, a transporter traditionally thought to reside only on cell membranes. The discovery shows MCT1 also sits in the inner mitochondrial membrane and, working with LDHB, enables lactate conversion to pyruvate and NADH to fuel the electron transport chain.

    “In the heart, lactate can enter mitochondria directly through a specific transporter protein and this process is essential for cardiac function under stress.”
    — Trace Thome and Zolt Arany
    1. 2 outlets How the Heart Stays Strong with MCT1-Dependent Mitochondrial Lactate Import

      first by Genetic Engineering and Biotechnology News, 14d ago · also Nature

      1 more headline