Study: Fat Tissue May Retain a Molecular 'Memory' of Past Obesity
Immune cells embedded in fat tissue undergo lasting changes that can hinder fat loss even after weight is lost, a new mouse study finds.
What to know
- A mouse study found that adipose tissue macrophages (ATMs) undergo lasting changes during obesity that persist after weight loss.
- These persistent immune-cell changes may help explain why regaining lost weight is common and why sustained fat loss is difficult.
- The research is in mice; it is not yet established how directly the findings translate to humans.
“There are infections that can cause long lasting changes to the immune system and related organs and Immunology is tightly linked to metabolism so I wouldn't be suprised if anorexia caused changes that persist for a long time”
Hoskuld, Reddit commenter · Reddit · Aug 29
Study researchers (unnamed in coverage) Authors of the mouse study
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What people are saying 1 voices from 1 site · best of 2 · verbatim
- Aug 30
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This is kind of interesting to me. I have lost 75 lbs over the last 2 years using a GLP1, exercising 4x a week, and eating much healthier. I was 210 lbs at my heaviest and I was there for about a decade (I’m 34.) My weight gain was due to uncontrolled PCOS and eating like garbage while not moving my body. I was also on psych meds that made me…