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HealthQuiet 14d · day 14

Long-term Cialis use tied to higher glaucoma risk in new study

Analysis of nearly 74,000 men found daily tadalafil use for urinary symptoms linked to a modest but statistically significant rise in glaucoma diagnoses.

newest coverage 13d agosummary written 13d ago5 pieces MastodonNewswiresReddit

What to know

  • Study of 36,927 long-term tadalafil users matched against 36,927 non-users found glaucoma diagnosed in 3.93% vs 3.16% over five years.
  • Researchers call it a 22% relative-risk increase, but the absolute gap is under one percentage point (about 77 extra diagnoses per 10,000 men).
  • The study covers men over 40 taking tadalafil regularly for urinary symptoms, not occasional use for erectile dysfunction or sexual activity.
  • No significant risk increase was found for low-tension or angle-closure glaucoma, only for open-angle glaucoma and high eye pressure.

Study researchers authors of the tadalafil-glaucoma study

Long-term Cialis use tied to higher glaucoma risk in new study
sciencealert.com

How it unfolded 2 developments, newest first · click a bar or a number to jump articlespostscomments

Peak 4 pieces in 4h at Sep 11, 6 AM; 5 pieces over 14 days (1 article · 3 posts · 1 comment) Sep 11, 6 AM — 4 pieces · 1 article · 2 posts · 1 comment — Reddit 2, Mastodon 1, Newswires 1Sep 11, 10 AM — quietSep 11, 2 PM — 1 piece · 1 post — Mastodon 1Sep 11, 6 PM — quietSep 11, 10 PM — quietSep 12, 2 AM — quietSep 12, 6 AM — quietSep 12, 10 AM — quietSep 12, 2 PM — quietSep 12, 6 PM — quietSep 12, 10 PM — quietSep 13, 2 AM — quietSep 13, 6 AM — quietSep 13, 10 AM — quietSep 13, 2 PM — quietSep 13, 6 PM — quietSep 13, 10 PM — quietSep 14, 2 AM — quietSep 14, 6 AM — quietSep 14, 10 AM — quietSep 14, 2 PM — quietSep 14, 6 PM — quietSep 14, 10 PM — quietSep 15, 2 AM — quietSep 15, 6 AM — quietSep 15, 10 AM — quietSep 15, 2 PM — quietSep 15, 6 PM — quietSep 15, 10 PM — quietSep 16, 2 AM — quietSep 16, 6 AM — quietSep 16, 10 AM — quietSep 16, 2 PM — quietSep 16, 6 PM — quietSep 16, 10 PM — quietSep 17, 2 AM — quietSep 17, 6 AM — quietSep 17, 10 AM — quietSep 17, 2 PM — quietSep 17, 6 PM — quietSep 17, 10 PM — quietSep 18, 2 AM — quietSep 18, 6 AM — quietSep 18, 10 AM — quietSep 18, 2 PM — quietSep 18, 6 PM — quietSep 18, 10 PM — quietSep 19, 2 AM — quietSep 19, 6 AM — quietSep 19, 10 AM — quietSep 19, 2 PM — quietSep 19, 6 PM — quietSep 19, 10 PM — quietSep 20, 2 AM — quietSep 20, 6 AM — quietSep 20, 10 AM — quietSep 20, 2 PM — quietSep 20, 6 PM — quietSep 20, 10 PM — quietSep 21, 2 AM — quietSep 21, 6 AM — quietSep 21, 10 AM — quietSep 21, 2 PM — quietSep 21, 6 PM — quietSep 21, 10 PM — quietSep 22, 2 AM — quietSep 22, 6 AM — quietSep 22, 10 AM — quietSep 22, 2 PM — quietSep 22, 6 PM — quietSep 22, 10 PM — quietSep 23, 2 AM — quietSep 23, 6 AM — quietSep 23, 10 AM — quietSep 23, 2 PM — quietSep 23, 6 PM — quietSep 23, 10 PM — quietYesterday, 2 AM — quietYesterday, 6 AM — quietYesterday, 10 AM — quietYesterday, 2 PM — quietYesterday, 6 PM — quietYesterday, 10 PM — quietToday, 2 AM — quietToday, 6 AM — quietToday, 10 AM — quiet 12
Sep 12Sep 13Sep 14Sep 15Sep 16Sep 17Sep 18Sep 19Sep 20Sep 21Sep 22Sep 23now · 11:58 AM ET
  1. 2

    Study coverage circulates on social platforms

    Mastodon and Reddit posts summarize the findings for wider audiences, framing it as a study of nearly 74,000 men linking tadalafil to glaucoma and eye pressure problems.

    “👨 ⚠️ A large study of nearly 74,000 men suggests that long-term use of tadalafil, best known as Cialis, may be linked to a higher risk of glaucoma and other eye pressure problems.”
    — TrueNorthSpice@mastodon.world, Mastodon poster · source
    • TrueNorthSpice@mastodon.world

      👨 ⚠️ A large study of nearly 74,000 men suggests that long-term use of tadalafil, best known as Cialis, may be linked to a higher risk of glaucoma and other eye pressure problems. Men prescribed the drug for urinary symptoms caused by an enlarged prostatate... read more in link # Men # Health https://www. sciencedaily.com/releases/2026…

      TrueNorthSpice@mastodon.worldMastodon13d agoview on Mastodon ↗
  2. 1

    Researchers propose eye-pressure mechanism for the link

    The article explains PDE5 inhibitors like tadalafil may widen ocular blood vessels and increase aqueous humor production, raising eye pressure that could damage the optic nerve over years of repeated use.

    “Yep, was originally used for chest pain and high blood pressure! Side effects included a raging unexplained erection.”
    — FuhrerInLaw, Reddit commenter · source

    • Yep, was originally used for chest pain and high blood pressure! Side effects included a raging unexplained erection.

      FuhrerInLawr/science14d agoview on r/science ↗
  3. background

    Study links long-term tadalafil use to higher glaucoma risk — Using the TriNetX Analytics Network, researchers matched 36,927 men on long-term tadalafil for urinary symptoms with 36,927 non-users and found glaucoma in 3.93% versus 3.16% over five years, a 22% relative increase.

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