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HealthQuiet 14d · day 15

Modified bone-marrow cell therapy nearly stops fractures in small osteoporosis trial

Ten women given fucose-treated MSCs saw fracture rates drop roughly tenfold in a small, uncontrolled study published in Cell.

newest coverage 13d agosummary written 13d ago5 pieces2 likes & upvotes NewswiresMastodonGoogle NewsReddit

What to know

  • Ten women with a history of frequent low-impact fractures received a single infusion of their own bone-marrow MSCs modified with a sugar (fucose) to help them home to bone.
  • Post-treatment fracture rate fell from about once every 1-2 years to about once per decade, sustained for several years with no reported side effects.
  • The trial had no control group and most participants continued conventional osteoporosis drugs, so it is unclear how much of the effect is due to the cell therapy alone.
  • Researchers did not directly track whether the modified cells reached the bones, leaving the mechanism of benefit unconfirmed.

“showed an almost 100% efficacy sustained for several years — and no side effects”

Ajit Varki, Independent physician-scientist, UC San Diego · Nature ↗ · Sep 10

Robert Sackstein Co-author; regenerative-medicine specialist, Miami VA Medical CenterJosé Moraleda Bone-marrow transplant specialist, University of MurciaAjit Varki Independent physician-scientist, UC San Diego

Modified bone-marrow cell therapy nearly stops fractures in small osteoporosis trial
nature.com

How it unfolded 1 development · click the chart to see its coverage articlesposts

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  1. 1

    Cell publishes trial results showing near-total fracture reduction

    The ten-woman trial reported in Cell and covered by Nature found fractures 'all but stopped' after a single infusion of modified bone-marrow cells, though the small, uncontrolled design and concurrent drug use leave key questions about causation unanswered.

    “It’s quite remarkable... showed an almost 100% efficacy sustained for several years — and no side effects…”
    — Ajit Varki
  2. background

    Spanish team led by José Moraleda begins human trial of modified cells — Clinical collaborators in Spain led by bone-marrow transplant specialist José Moraleda at the University of Murcia began testing fucose-modified autologous MSCs in women with osteoporosis, the first trial to deliberately modify cell trafficking for this purpose.

  3. background

    Sackstein's team shows fucose-modified MSCs home to bone in mice — Robert Sackstein and colleagues found that adding a sugar called fucose to mesenchymal stromal cells let the cells seek out and enter bone, generating skeletal tissue in mice, laying the groundwork for a human trial.

Also covered reported alongside — the timeline has no entry for these yet

  1. 2 outlets Osteoporosis affects millions: could modified cells rebuild their bones?

    first by nature.com, 13d ago · also Nature News