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ScienceQuiet 11d · day 15

Scientists develop WHOLISTIC imaging to watch cell communication across entire living organisms

New technique reveals real-time cellular conversations in transparent fish, bridging a fundamental gap in biology.

newest coverage 11d agosummary written 12d ago5 pieces33 likes & upvotes1 comments NewswiresMastodonGoogle NewsBluesky

What to know

  • WHOLISTIC, a new imaging technique using fluorescent calcium sensors, allows researchers to watch cellular communication across an entire living organism in real time—closing a fundamental observability gap in biology.
  • The method has revealed previously unknown interactions: cartilage responding to cold, brain protective tissues responding to ketamine, and coordinated blood-flow redistribution controlled by the brainstem.
  • Tested so far on naturally transparent fish (larval zebrafish and adult Danionella cerebrum), the technique could help scientists understand similar systems in human bodies and is intended for adoption across research fields.

“This now allows all these fields – physiology, neuroscience, behavior, cell biology – to connect and study all of them in the same animal”

Misha Ahrens, Neuroscientist, lab host · ScienceAlert ↗

Virginie Ruetten Computational neuroscientist, technique developerMisha Ahrens Neuroscientist, lab hostHoward Hughes Medical Institute Research institution

Scientists develop WHOLISTIC imaging to watch cell communication across entire living organisms
sciencealert.com

How it unfolded 2 developments, newest first · click a bar or a number to jump articlesposts

Peak 2 pieces in 4h at Sep 11, 7 PM; 5 pieces over 15 days (2 articles · 3 posts) Sep 9, 11 AM — 1 piece · 1 article — Google News 1Sep 9, 3 PM — quietSep 9, 7 PM — quietSep 9, 11 PM — quietSep 10, 3 AM — quietSep 10, 7 AM — quietSep 10, 11 AM — quietSep 10, 3 PM — quietSep 10, 7 PM — quietSep 10, 11 PM — quietSep 11, 3 AM — quietSep 11, 7 AM — quietSep 11, 11 AM — quietSep 11, 3 PM — quietSep 11, 7 PM — 2 pieces · 1 article · 1 post — Mastodon 1, Newswires 1Sep 11, 11 PM — quietSep 12, 3 AM — 1 piece · 1 post — Bluesky 1Sep 12, 7 AM — quietSep 12, 11 AM — quietSep 12, 3 PM — quietSep 12, 7 PM — quietSep 12, 11 PM — 1 piece · 1 post — Mastodon 1Sep 13, 3 AM — quietSep 13, 7 AM — quietSep 13, 11 AM — quietSep 13, 3 PM — quietSep 13, 7 PM — quietSep 13, 11 PM — quietSep 14, 3 AM — quietSep 14, 7 AM — quietSep 14, 11 AM — quietSep 14, 3 PM — quietSep 14, 7 PM — quietSep 14, 11 PM — quietSep 15, 3 AM — quietSep 15, 7 AM — quietSep 15, 11 AM — quietSep 15, 3 PM — quietSep 15, 7 PM — quietSep 15, 11 PM — quietSep 16, 3 AM — quietSep 16, 7 AM — quietSep 16, 11 AM — quietSep 16, 3 PM — quietSep 16, 7 PM — quietSep 16, 11 PM — quietSep 17, 3 AM — quietSep 17, 7 AM — quietSep 17, 11 AM — quietSep 17, 3 PM — quietSep 17, 7 PM — quietSep 17, 11 PM — quietSep 18, 3 AM — quietSep 18, 7 AM — quietSep 18, 11 AM — quietSep 18, 3 PM — quietSep 18, 7 PM — quietSep 18, 11 PM — quietSep 19, 3 AM — quietSep 19, 7 AM — quietSep 19, 11 AM — quietSep 19, 3 PM — quietSep 19, 7 PM — quietSep 19, 11 PM — quietSep 20, 3 AM — quietSep 20, 7 AM — quietSep 20, 11 AM — quietSep 20, 3 PM — quietSep 20, 7 PM — quietSep 20, 11 PM — quietSep 21, 3 AM — quietSep 21, 7 AM — quietSep 21, 11 AM — quietSep 21, 3 PM — quietSep 21, 7 PM — quietSep 21, 11 PM — quietSep 22, 3 AM — quietSep 22, 7 AM — quietSep 22, 11 AM — quietSep 22, 3 PM — quietSep 22, 7 PM — quietSep 22, 11 PM — quietYesterday, 3 AM — quietYesterday, 7 AM — quietYesterday, 11 AM — quietYesterday, 3 PM — quietYesterday, 7 PM — quietYesterday, 11 PM — quietToday, 3 AM — quiet 12
Sep 10Sep 12Sep 14Sep 16Sep 18Sep 20Sep 22now · 7:45 AM ET
  1. 2

    WHOLISTIC imaging reveals unknown cross-organ interactions in transparent fish

    Testing on larval zebrafish and adult Danionella cerebrum reveals unexpected findings: cartilage cells responding to cold, brain meninges responding to ketamine, unknown muscle synergies, and brainstem-controlled blood flow redistribution across the body.

    “At the whole-organism scale, the method captured brainstem-controlled redistribution of body-wide blood flow…”
    — WHOLISTIC research authors
    1. 1 outlet Scientists Can Now Watch 'Conversations' Between Cells Across The Body of a Living Animal

      first by ScienceAlert, 12d ago

    • oden-gjallarhornet.bsky.social

      For The First Time, Watch Cells Communicate Across an Entire Living Body

      oden-gjallarhornet.bsky.socialBluesky12d ago33▲view on Bluesky ↗
  2. 1

    Howard Hughes team publishes WHOLISTIC imaging technique in Nature

    Researchers led by computational neuroscientist Virginie Ruetten present a new method called WHOLISTIC that captures cellular activity across an entire organism second by second using genetically engineered fluorescent calcium sensors.

    “This work bridges two fundamental scales of biology – the cell and the organism – such that we can now fill that observability gap…”
    — Virginie Ruetten