conv.

All stories
ScienceQuiet 7d · day 14

Psilocybin pretreatment prevents chemotherapy nerve damage in mice

Two doses of the psychedelic compound before chemo fully blocked neuropathy in a new mouse study published in Science.

newest coverage 7d agosummary written 12d ago4 pieces146 likes & upvotes4 comments Google NewsBlueskyNewswires

What to know

  • Two doses of psilocybin given before each of six chemotherapy rounds over eight months fully prevented neuropathy in mice.
  • Chemotherapy-induced neuropathy affects up to 60% of patients on platinum-based cancer drugs, with no effective prevention or treatment currently available.
  • Psilocybin did not reduce chemotherapy's ability to shrink tumors, and works by keeping mitochondria moving in sensory nerve fibers.
  • Findings are from mouse studies published in Science; human application has not yet been tested per the evidence provided.

Moran Amit Study co-author, surgical oncologistJoe Cichon Neuroanaesthesiologist, University of Pennsylvania

Psilocybin pretreatment prevents chemotherapy nerve damage in mice
go.nature.com

How it unfolded 1 development · click the chart to see its coverage articlesposts

Peak 1 piece in 3h at Sep 10, 1 PM; 4 pieces over 14 days (2 articles · 2 posts) Sep 10, 1 PM — 1 piece · 1 article — Google News 1Sep 10, 4 PM — quietSep 10, 7 PM — quietSep 10, 10 PM — quietSep 11, 1 AM — quietSep 11, 4 AM — quietSep 11, 7 AM — quietSep 11, 10 AM — quietSep 11, 1 PM — quietSep 11, 4 PM — quietSep 11, 7 PM — quietSep 11, 10 PM — quietSep 12, 1 AM — 1 piece · 1 post — Bluesky 1Sep 12, 4 AM — quietSep 12, 7 AM — quietSep 12, 10 AM — quietSep 12, 1 PM — 1 piece · 1 post — Bluesky 1Sep 12, 4 PM — quietSep 12, 7 PM — quietSep 12, 10 PM — quietSep 13, 1 AM — quietSep 13, 4 AM — quietSep 13, 7 AM — quietSep 13, 10 AM — quietSep 13, 1 PM — quietSep 13, 4 PM — quietSep 13, 7 PM — quietSep 13, 10 PM — quietSep 14, 1 AM — quietSep 14, 4 AM — quietSep 14, 7 AM — quietSep 14, 10 AM — quietSep 14, 1 PM — quietSep 14, 4 PM — quietSep 14, 7 PM — quietSep 14, 10 PM — quietSep 15, 1 AM — quietSep 15, 4 AM — quietSep 15, 7 AM — quietSep 15, 10 AM — quietSep 15, 1 PM — quietSep 15, 4 PM — quietSep 15, 7 PM — quietSep 15, 10 PM — quietSep 16, 1 AM — quietSep 16, 4 AM — quietSep 16, 7 AM — quietSep 16, 10 AM — quietSep 16, 1 PM — quietSep 16, 4 PM — quietSep 16, 7 PM — quietSep 16, 10 PM — 1 piece · 1 article — Newswires 1Sep 17, 1 AM — quietSep 17, 4 AM — quietSep 17, 7 AM — quietSep 17, 10 AM — quietSep 17, 1 PM — quietSep 17, 4 PM — quietSep 17, 7 PM — quietSep 17, 10 PM — quietSep 18, 1 AM — quietSep 18, 4 AM — quietSep 18, 7 AM — quietSep 18, 10 AM — quietSep 18, 1 PM — quietSep 18, 4 PM — quietSep 18, 7 PM — quietSep 18, 10 PM — quietSep 19, 1 AM — quietSep 19, 4 AM — quietSep 19, 7 AM — quietSep 19, 10 AM — quietSep 19, 1 PM — quietSep 19, 4 PM — quietSep 19, 7 PM — quietSep 19, 10 PM — quietSep 20, 1 AM — quietSep 20, 4 AM — quietSep 20, 7 AM — quietSep 20, 10 AM — quietSep 20, 1 PM — quietSep 20, 4 PM — quietSep 20, 7 PM — quietSep 20, 10 PM — quietSep 21, 1 AM — quietSep 21, 4 AM — quietSep 21, 7 AM — quietSep 21, 10 AM — quietSep 21, 1 PM — quietSep 21, 4 PM — quietSep 21, 7 PM — quietSep 21, 10 PM — quietSep 22, 1 AM — quietSep 22, 4 AM — quietSep 22, 7 AM — quietSep 22, 10 AM — quietSep 22, 1 PM — quietSep 22, 4 PM — quietSep 22, 7 PM — quietSep 22, 10 PM — quietYesterday, 1 AM — quietYesterday, 4 AM — quietYesterday, 7 AM — quietYesterday, 10 AM — quietYesterday, 1 PM — quietYesterday, 4 PM — quietYesterday, 7 PM — quietYesterday, 10 PM — quietToday, 1 AM — quietToday, 4 AM — quiet 1
Sep 11Sep 12Sep 13Sep 14Sep 15Sep 16Sep 17Sep 18Sep 19Sep 20Sep 21Sep 22now · 7:45 AM ET
  1. 1

    Researchers detail mitochondria-based mechanism behind the effect

    The authors found psilocybin activates receptors on sensory nerve fibers in the skin that recruit motor proteins to keep energy-producing mitochondria moving along neurons, preventing the nerve-tip degeneration that causes chronic pain; outside experts called the prevention-focused strategy notable.

    “clever treatment approach…”
    — Joe Cichon
    • nature.com

      Just two doses of psilocybin administered before chemotherapy completely prevented mice from developing neuropathy go.

      nature.comBluesky12d ago82▲view on Bluesky ↗
    1 more of the top 2 · 2 posts in this stretch
    • paulstamets.bsky.social

      The potential of #psilocybin continues to surprise us! 🆕research has found that psilocybin prevented #chemotherapy -induced peripheral neuropathy #CIPN in mouse models, a painful & often irreversible side effect of #cancer treatment for which there is currently no proven preventive strategy. 1/2

      paulstamets.bsky.socialBluesky11d ago64▲view on Bluesky ↗
    all of them →
  2. background

    Study finds psilocybin blocks chemo-induced neuropathy in mice — A study published in Science reports that two doses of psilocybin given before each of six rounds of chemotherapy over eight months completely prevented mice from developing neuropathy, without reducing the chemotherapy's tumor-shrinking effect.

Also covered reported alongside — the timeline has no entry for these yet

  1. 2 outlets Psilocybin Prevents Chemotherapy-Related Nerve Injury in Mice

    first by Cancer Health, 13d ago · also Medscape

    1 more headline

What people are saying 0 voices from 0 sites · best of 2 · verbatim