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ScienceQuiet 9d · day 11

Fish show heightened sensitivity to antidepressants in water, study finds

Research on two fish species reveals their monoamine transporters respond to antidepressants at concentrations up to 10 times lower than human equivalents.

newest coverage 8d agosummary written 8d ago3 pieces NewswiresGoogle NewsMastodon

What to know

  • Fish monoamine transporters—particularly SERTa—are significantly more sensitive to antidepressants than human equivalents, sometimes responding at concentrations 10+ times lower.
  • Antidepressants and their metabolites persist in wastewater and reach aquatic environments, exposing fish to these pharmaceuticals.
  • The heightened sensitivity raises questions about behavioral and physiological effects on fish populations and broader ecosystem impacts.

“Many of the drugs that target human brain chemistry, such as antidepressants, are still biologically active when they leave the body.”

Phys.org/Environmental Science & Technology study · Phys.org ↗

Professor Shinichi Miyagawa Lead researcher, Tokyo University of ScienceProfessor Masaru Ihara Co-researcher, Kochi University

Fish show heightened sensitivity to antidepressants in water, study finds
eurasiareview.com

How it unfolded 1 development · click the chart to see its coverage articlesposts

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  1. 1

    Antidepressant metabolites persist in waterways and reach aquatic life

    The research highlights that antidepressants and their metabolites remain biologically active after leaving the human body, persisting in wastewater and eventually entering seas, rivers, and other aquatic environments where fish are exposed to them.

  2. background

    Fish SERTa transporters respond at lower drug concentrations than human SERT — The study examined medaka and ayu fish species and found that fish SERTa transporters responded to antidepressants at concentrations sometimes more than ten times lower than human SERT. The research also identified that some drugs not typically thought to affect these proteins in humans still altered fish versions.

  3. background

    Study reveals fish sensitivity to antidepressants in waterways — Research led by Professor Shinichi Miyagawa of Tokyo University of Science and Professor Masaru Ihara of Kochi University, published in Environmental Science & Technology, demonstrates that fish monoamine transporters—proteins that regulate serotonin, dopamine, and norepinephrine—respond more sensitively to antidepressants than human equivalents.