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HealthQuiet 5d · day 10

Placenta-derived nasal spray shows promise against Alzheimer's in mice

Italian researchers report that extracellular vesicles from placental cells reduce neuroinflammation and preserve memory in transgenic mice.

newest coverage 5d agosummary written 6d ago8 pieces RedditNewswiresMastodonGoogle News

What to know

  • Italian researchers developed a nasal spray containing extracellular vesicles from human placental cells that improved cognitive performance in Alzheimer's disease transgenic mice over six months of treatment.
  • The spray reduced amyloid-beta deposits and neuroinflammation in the hippocampus while boosting neuroplasticity-related proteins, without affecting tau phosphorylation.
  • The same vesicles reduced neuronal deterioration when tested on human neurons derived from Alzheimer's disease patients, suggesting translational potential.

“A particularly promising avenue within regenerative medicine involves harnessing the therapeutic potential of extracellular vesicles, particularly those isolated from mesenchymal stromal cells (MSCs).”

Research team, Study authors · ScienceAlert ↗

Andrea Papait Lead author, cell biologistCatholic University of the Sacred Heart Research institution

Placenta-derived nasal spray shows promise against Alzheimer's in mice
sciencealert.com

How it unfolded 2 developments, newest first · click a bar or a number to jump articlesposts

Peak 6 pieces in 3h at Sep 15, 8 PM; 8 pieces over 10 days (6 articles · 2 posts) Sep 14, 5 AM — 1 piece · 1 post — Reddit 1Sep 14, 8 AM — quietSep 14, 11 AM — quietSep 14, 2 PM — quietSep 14, 5 PM — quietSep 14, 8 PM — quietSep 14, 11 PM — quietSep 15, 2 AM — quietSep 15, 5 AM — quietSep 15, 8 AM — quietSep 15, 11 AM — quietSep 15, 2 PM — quietSep 15, 5 PM — quietSep 15, 8 PM — 6 pieces · 5 articles · 1 post — Google News 4, Mastodon 1, Newswires 1Sep 15, 11 PM — quietSep 16, 2 AM — quietSep 16, 5 AM — quietSep 16, 8 AM — quietSep 16, 11 AM — quietSep 16, 2 PM — quietSep 16, 5 PM — quietSep 16, 8 PM — quietSep 16, 11 PM — quietSep 17, 2 AM — quietSep 17, 5 AM — quietSep 17, 8 AM — quietSep 17, 11 AM — quietSep 17, 2 PM — quietSep 17, 5 PM — quietSep 17, 8 PM — quietSep 17, 11 PM — quietSep 18, 2 AM — quietSep 18, 5 AM — quietSep 18, 8 AM — quietSep 18, 11 AM — quietSep 18, 2 PM — quietSep 18, 5 PM — 1 piece · 1 article — Google News 1Sep 18, 8 PM — quietSep 18, 11 PM — quietSep 19, 2 AM — quietSep 19, 5 AM — quietSep 19, 8 AM — quietSep 19, 11 AM — quietSep 19, 2 PM — quietSep 19, 5 PM — quietSep 19, 8 PM — quietSep 19, 11 PM — quietSep 20, 2 AM — quietSep 20, 5 AM — quietSep 20, 8 AM — quietSep 20, 11 AM — quietSep 20, 2 PM — quietSep 20, 5 PM — quietSep 20, 8 PM — quietSep 20, 11 PM — quietSep 21, 2 AM — quietSep 21, 5 AM — quietSep 21, 8 AM — quietSep 21, 11 AM — quietSep 21, 2 PM — quietSep 21, 5 PM — quietSep 21, 8 PM — quietSep 21, 11 PM — quietSep 22, 2 AM — quietSep 22, 5 AM — quietSep 22, 8 AM — quietSep 22, 11 AM — quietSep 22, 2 PM — quietSep 22, 5 PM — quietSep 22, 8 PM — quietSep 22, 11 PM — quietYesterday, 2 AM — quietYesterday, 5 AM — quietYesterday, 8 AM — quietYesterday, 11 AM — quietYesterday, 2 PM — quietYesterday, 5 PM — quietYesterday, 8 PM — quietYesterday, 11 PM — quietToday, 2 AM — quiet 12
Sep 15Sep 16Sep 17Sep 18Sep 19Sep 20Sep 21Sep 22now · 5:47 AM ET
  1. 2

    Full study details emerge: spray reduced amyloid-beta and neuroinflammation

    ScienceAlert published comprehensive coverage showing the nasal spray significantly reduced amyloid-beta deposits in the hippocampus and lowered neuroinflammation by reducing activation of astrocytes and microglia. Behavioral tests confirmed improved object recognition and spatial memory in treated mice, while separate experiments on human Alzheimer's patient-derived neurons showed the EV treatment reduced neuronal deterioration.

    “MSC-derived EVs (MSC-EVs) are nanoparticles that mediate intercellular communication and have been demonstrated to potentially deliver bioactive molecules with anti-inflammatory and neuroprotective properties.”
    — Andrea Papait, lead author
  2. 1 day quiet
  3. 1

    Study shows placenta-derived nasal spray protects neurons in Alzheimer's mouse model

    Researchers from Catholic University of the Sacred Heart in Italy published findings that a nasal spray containing human amniotic mesenchymal stromal cell-derived vesicles (hAMSC-EVs) improved cognitive performance in transgenic mice engineered to develop Alzheimer's disease when administered twice weekly for six months.

    1. 4 outlets Could a Nasal Spray Preserve Memory in Alzheimer’s Disease?

      first by Technology Networks, 8d ago · also Drug Target Review, ScienceAlert, Eurasia Review

      4 more headlines