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1. 1 Sep 16

   WHO declares ongoing outbreak a graded health emergency

   The WHO classifies the multi-country mpox outbreak as a graded health emergency and extends standing recommendations on mpox through August 2027, reversing the emergency downgrade declared by Africa CDC in January.

   “reported weekly confirmed cases have remained somewhat stable on the continent, with about 200 cases per week in recent weeks…”

2. backgroundSep 14

   WHO publishes multi-country situation report, confirms clade Ib spread to Europe — The WHO releases its Mpox: Multi-country External Situation Report documenting the six-week period data and noting that Chile and Hungary reported clade Ib mpox for the first time, while community transmission of clade Ib was confirmed in nine European countries, with Spain reporting the highest cumulative total (241 cases). Madagascar is described as having the largest mpox outbreak globally since December 2025.

3. backgroundAug 16

   WHO documents 1,153 cases across 11 African countries in six weeks — By the end of the surveillance period, 11 African countries recorded 1,153 confirmed mpox cases and seven deaths, with Madagascar leading at 785 cases, followed by Angola (184), Kenya (94), DRC (41), and Cameroon (28). WHO noted weekly confirmed cases remained stable at about 200 per week but cautioned figures could be underestimated due to reporting delays and reduced surveillance.

4. backgroundJul 6

   Six-week mpox surveillance period begins in African region — A six-week tracking period begins (July 6 to August 16) that would later show continued active transmission of mpox across 11 African countries despite the January emergency declaration lift.

5. backgroundJan 1

   Africa CDC declares end to mpox emergency — The Africa Centres for Disease Control and Prevention lifts the mpox Public Health Emergency of Continental Security declaration, citing a 40 percent fall in suspected cases and 60 percent fall in confirmed cases between early and late 2025, while emphasizing that mpox remained endemic and vaccination would remain central to response.

6. backgroundJan 1, 2025

   Multi-country mpox outbreak begins affecting African region — An mpox outbreak emerges that would eventually affect 35 African countries, with the WHO later reporting 52,424 confirmed cases and 238 deaths across the continent between January 1, 2025 and August 16, 2026.