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ScienceQuiet 7d · day 9

Study shows gut immune cells migrate to brain after infection

Researchers find that stomach infections trigger protective immune cells to travel to the brain's protective membranes, where they establish lasting memory.

newest coverage 7d agosummary written 7d ago5 pieces1 likes & upvotes NewswiresMastodonGoogle News

What to know

  • Immune cells activated by intestinal infections migrate from the gut to the brain's protective meninges, establishing long-lasting immune memory.
  • The finding reveals a previously understudied connection between gastrointestinal health and the central nervous system.
  • Researchers identified identical T-cell receptors in gut and meningeal tissue, confirming cells travel via bloodstream using chemokine signaling.
  • The discovery could lead to therapies targeting gut-brain immune pathways for neurological disorders.

“The study is 'outstanding' and could help researchers to learn more about how the gut interacts with the central nervous system.”

Francisco Quintana, Neuroimmunologist, Harvard University · Nature ↗

Menna Clatworthy Study co-author, clinician scientistFrancisco Quintana Neuroimmunologist, Harvard University

Study shows gut immune cells migrate to brain after infection
nature.com

How it unfolded 2 developments, newest first · click a bar or a number to jump articlesposts

Peak 2 pieces in 3h at Sep 14, 7 PM; 5 pieces over 9 days (2 articles · 3 posts) Sep 14, 7 PM — 2 pieces · 1 article · 1 post — Mastodon 1, Newswires 1Sep 14, 10 PM — quietSep 15, 1 AM — quietSep 15, 4 AM — quietSep 15, 7 AM — quietSep 15, 10 AM — quietSep 15, 1 PM — 1 piece · 1 article — Google News 1Sep 15, 4 PM — quietSep 15, 7 PM — 1 piece · 1 post — Mastodon 1Sep 15, 10 PM — quietSep 16, 1 AM — quietSep 16, 4 AM — quietSep 16, 7 AM — quietSep 16, 10 AM — quietSep 16, 1 PM — quietSep 16, 4 PM — quietSep 16, 7 PM — quietSep 16, 10 PM — quietSep 17, 1 AM — 1 piece · 1 post — Mastodon 1Sep 17, 4 AM — quietSep 17, 7 AM — quietSep 17, 10 AM — quietSep 17, 1 PM — quietSep 17, 4 PM — quietSep 17, 7 PM — quietSep 17, 10 PM — quietSep 18, 1 AM — quietSep 18, 4 AM — quietSep 18, 7 AM — quietSep 18, 10 AM — quietSep 18, 1 PM — quietSep 18, 4 PM — quietSep 18, 7 PM — quietSep 18, 10 PM — quietSep 19, 1 AM — quietSep 19, 4 AM — quietSep 19, 7 AM — quietSep 19, 10 AM — quietSep 19, 1 PM — quietSep 19, 4 PM — quietSep 19, 7 PM — quietSep 19, 10 PM — quietSep 20, 1 AM — quietSep 20, 4 AM — quietSep 20, 7 AM — quietSep 20, 10 AM — quietSep 20, 1 PM — quietSep 20, 4 PM — quietSep 20, 7 PM — quietSep 20, 10 PM — quietSep 21, 1 AM — quietSep 21, 4 AM — quietSep 21, 7 AM — quietSep 21, 10 AM — quietSep 21, 1 PM — quietSep 21, 4 PM — quietSep 21, 7 PM — quietSep 21, 10 PM — quietSep 22, 1 AM — quietSep 22, 4 AM — quietSep 22, 7 AM — quietSep 22, 10 AM — quietSep 22, 1 PM — quietSep 22, 4 PM — quietSep 22, 7 PM — quietSep 22, 10 PM — quietYesterday, 1 AM — quietYesterday, 4 AM — quietYesterday, 7 AM — quietYesterday, 10 AM — quietYesterday, 1 PM — quietYesterday, 4 PM — quietYesterday, 7 PM — quietYesterday, 10 PM — quietToday, 1 AM — quietToday, 4 AM — quiet 1–2
Sep 15Sep 16Sep 17Sep 18Sep 19Sep 20Sep 21Sep 22now · 5:47 AM ET
  1. 1

    Harvard neuroimmunologist calls findings outstanding with broad implications

    Francisco Quintana, a neuroimmunologist at Harvard University, praised the study and outlined its significance for understanding gut-brain interactions. He highlighted potential applications in exploring how gut infections affect neurological disorders and developing new therapies.

    “It opens up several possibilities, such as exploring how gut infections might affect neurological disorders, and developing therapies that harness that relationship.”
    — Francisco Quintana
  2. 2

    Study finds gut immune cells migrate to brain after infection

    Researchers led by Menna Clatworthy at the University of Cambridge published findings in Nature Neuroscience showing that CD4+ T cells activated by intestinal pathogens travel from the gut to the meninges surrounding the brain. The immune cells become resident populations that maintain a memory of past infections for over a month.

    “Immune cells that fight stomach bugs can migrate from the gut to the brain, where they establish a lasting 'memory' of previous infection, according to a study in mice.”
    — Nature News
    1. 2 outlets ‘Stomach bugs’ send protective immune cells rushing from gut to brain

      first by Nature, 8d ago · also Nature News