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1. 2 Sep 17

   Findings suggest path to targeted MS treatments

   The research identifies B cells and ABC-like B cells as key immune cells showing the strongest changes before relapse, with EBV proteins triggering MS risk genes. Senior author Chitnis notes the results point toward more precise therapeutic approaches targeting EBV or specific immune cells, rather than broad immune suppression.

   “Currently, most MS treatments work by broadly suppressing the immune system. Our results suggest there's an opportunity to be more precise and develop approaches that target EBV or the immune cells involved in relapse.”

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2. 1 Sep 16

   Mass General study identifies EBV activity before MS relapse

   Researchers analyzing blood samples from 114 MS patients and 21 healthy controls detected increased EBV lytic activity in immune cells up to 90 days before MS relapse, with elevated expression of MS-risk genes appearing only in pre-relapse periods. The study tracked immune changes across the CLIMB cohort at Brigham and Women's Hospital.

   “We believe this work provides foundational insights into the cause of multiple sclerosis. This study puts all the pieces together, showing a timeline of how the reactivated virus interacts with risk genes to unleash inflammation before relapse occurs.”