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ScienceQuiet 2d · day 3

Engineered E. coli probiotic eliminates 43% of colorectal tumors in mice

Researchers developed a genetically modified bacterium that delivers chemotherapy, immune stimulation, and checkpoint blockade directly to tumors.

newest coverage 2d agosummary written 2d ago6 pieces74 likes & upvotes3 comments NewswiresGoogle NewsMastodonRedditX

What to know

  • Engineered E. coli bacterium achieved 43% tumor elimination rate in mouse colorectal cancer models.
  • The modified probiotic delivers three concurrent therapies: direct chemotherapy production, immune stimulation, and checkpoint blockade.
  • This is early-stage research; human trials would be the next step in the development pipeline.

ScienceAlert Science journalism outlet

How it unfolded 1 development · click the chart to see its coverage articlesposts

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Sep 21Sep 22yesterdaynow · 12:59 AM ET
  1. 1

    Engineered probiotic shows 43% tumor elimination in mice

    ScienceAlert reports that researchers have engineered an E. coli probiotic that wipes out 43% of colorectal tumors in mice. The engineered bacterium delivers chemotherapy directly inside the tumor, an immune stimulant, and a localized form of immune checkpoint blockade.

    “The engineered E Coli packed a triple-whammy – chemotherapy produced directly inside the tumor, an immune stimulant, and a localized form of immune checkpoint blockade.”
    — mvea, Reddit user · source
    1. 1 outlet Engineered Probiotic Wipes Out 43% of Colorectal Tumors in Mice

      first by ScienceAlert, 3d ago

    • Two fascinating cancer breakthroughs are happening at same time. First, a engineered probiotic bacteria attack 43% of colorectal tumors in mice. This bacteria can produce chemotherapy inside tumors while also activating the immune system. In mice, this treatment completely

      @SciTecheraX2d ago74▲view on X ↗
    1 more of the top 2 · 2 posts in this stretch

    • Well the country that you hate also contributes over 50% of global funding to cancer research.

      munchi333r/science2d agoview on r/science ↗
    all of them →

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