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ScienceQuiet 13d · day 13

ETH Zurich develops RNA archiving method to reveal cells' past activity

Researchers can now reconstruct gene activity from days past by preserving RNA molecules inside cells, opening new possibilities for studying immune and cancer responses.

newest coverage 13d agosummary written 12d ago6 pieces RedditGoogle News

What to know

  • ETH Zurich researchers have created a method to archive RNA molecules inside cells, allowing them to reconstruct past gene activity over several days—solving a long-standing limitation where only snapshot measurements were possible.
  • The technique uses three optimized proteins to protect RNA around cell mitochondria, preserving thousands of RNA molecules that would normally degrade within hours.
  • The breakthrough enables detection of short-lived immune and stress responses that researchers would miss with conventional measurement methods, with potential applications in cancer research and understanding drug resistance.

Christopher Reinkemeier Postdoctoral researcher, ETH ZurichMarcos Manero Carranza Doctoral student, ETH ZurichRandall Platt Professor, ETH Zurich Department of Biosystems Science and EngineeringETH Zurich Department of Biosystems Science and Engineering Research institution

ETH Zurich develops RNA archiving method to reveal cells' past activity
eurekalert.org

How it unfolded 3 developments, newest first · click a bar or a number to jump articlesposts

Peak 4 pieces in 3h at Oct 26, 7 AM; 6 pieces over 14 days (4 articles · 2 posts) Oct 26, 1 AM — 2 pieces · 2 articles — Google News 2Oct 26, 4 AM — quietOct 26, 7 AM — 4 pieces · 2 articles · 2 posts — Reddit 2, Google News 2Oct 26, 10 AM — quietOct 26, 1 PM — quietOct 26, 4 PM — quietOct 26, 7 PM — quietOct 26, 10 PM — quietOct 27, 1 AM — quietOct 27, 4 AM — quietOct 27, 7 AM — quietOct 27, 10 AM — quietOct 27, 1 PM — quietOct 27, 4 PM — quietOct 27, 7 PM — quietOct 27, 10 PM — quietOct 28, 1 AM — quietOct 28, 4 AM — quietOct 28, 7 AM — quietOct 28, 10 AM — quietOct 28, 1 PM — quietOct 28, 4 PM — quietOct 28, 7 PM — quietOct 28, 10 PM — quietOct 29, 1 AM — quietOct 29, 4 AM — quietOct 29, 7 AM — quietOct 29, 10 AM — quietOct 29, 1 PM — quietOct 29, 4 PM — quietOct 29, 7 PM — quietOct 29, 10 PM — quietOct 30, 1 AM — quietOct 30, 4 AM — quietOct 30, 7 AM — quietOct 30, 10 AM — quietOct 30, 1 PM — quietOct 30, 4 PM — quietOct 30, 7 PM — quietOct 30, 10 PM — quietOct 31, 1 AM — quietOct 31, 4 AM — quietOct 31, 7 AM — quietOct 31, 10 AM — quietOct 31, 1 PM — quietOct 31, 4 PM — quietOct 31, 7 PM — quietOct 31, 10 PM — quietNov 1, 1 AM — quietNov 1, 3 AM — quietNov 1, 6 AM — quietNov 1, 9 AM — quietNov 1, 12 PM — quietNov 1, 3 PM — quietNov 1, 6 PM — quietNov 1, 9 PM — quietNov 2, 12 AM — quietNov 2, 3 AM — quietNov 2, 6 AM — quietNov 2, 9 AM — quietNov 2, 12 PM — quietNov 2, 3 PM — quietNov 2, 6 PM — quietNov 2, 9 PM — quietNov 3, 12 AM — quietNov 3, 3 AM — quietNov 3, 6 AM — quietNov 3, 9 AM — quietNov 3, 12 PM — quietNov 3, 3 PM — quietNov 3, 6 PM — quietNov 3, 9 PM — quietNov 4, 12 AM — quietNov 4, 3 AM — quietNov 4, 6 AM — quietNov 4, 9 AM — quietNov 4, 12 PM — quietNov 4, 3 PM — quietNov 4, 6 PM — quietNov 4, 9 PM — quietNov 5, 12 AM — quietNov 5, 3 AM — quietNov 5, 6 AM — quietNov 5, 9 AM — quietNov 5, 12 PM — quietNov 5, 3 PM — quietNov 5, 6 PM — quietNov 5, 9 PM — quietNov 6, 12 AM — quietNov 6, 3 AM — quietNov 6, 6 AM — quietNov 6, 9 AM — quietNov 6, 12 PM — quietNov 6, 3 PM — quietNov 6, 6 PM — quietNov 6, 9 PM — quietYesterday, 12 AM — quietYesterday, 3 AM — quietYesterday, 6 AM — quietYesterday, 9 AM — quietYesterday, 12 PM — quietYesterday, 3 PM — quietYesterday, 6 PM — quietYesterday, 9 PM — quietToday, 12 AM — quietToday, 3 AM — quietToday, 6 AM — quietToday, 9 AM — quiet 1–3
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  1. 3

    Researchers apply for patent and plan future cancer research applications

    ETH Zurich researchers have applied for a patent on the RNA archiving technology and plan to develop it further for applications in animal models and cancer research, with particular interest in studying how cancer cells survive treatment.

  2. 1

    Study demonstrates method on human cells responding to immune signaling

    Researchers show how the new archiving technique works by studying human cells in culture responding to immune system signaling molecules. The approach solves a key limitation of conventional RNA measurement: the inability to detect short-lived gene responses that have already occurred by the time measurement takes place.

    “If you measure too late with the conventional method, you no longer see that the response has even taken place.”
    — Marcos Manero Carranza
    1. 2 outlets RNA archiving method reveals what a cell did days ago

      first by Phys.org, 13d ago · also ETH Zürich

      1 more headline
  3. 2

    ETH Zurich researchers develop RNA archiving method

    Scientists at ETH Zurich's Department of Biosystems Science and Engineering announce a new method that archives RNA molecules in cells, enabling researchers to examine not only a cell's current state but also reconstruct which genes were active in the past. The method uses three optimized proteins to concentrate RNA in a film around cell mitochondria, protecting it from natural breakdown.

    “Among other reasons, this glimpse into the past is of interest because it tells you about a cell's short-lived responses – of which there are many. Immune and stress responses are just a few examples.”
    — Christopher Reinkemeier

Also covered reported alongside — the timeline has no entry for these yet

  1. 1 outlet New Method Reveals What Cell Did Days Ago

    first by Mirage News, 13d ago

    1 more headline